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Friday, July 17, 2020 | History

2 edition of Chemical mutagenesis in laboratory mammals found in the catalog.

Chemical mutagenesis in laboratory mammals

Edward von Halle

Chemical mutagenesis in laboratory mammals

a bibliography on the effects of chemicals on germ cells

by Edward von Halle

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  • 7 Currently reading

Published by Oak Ridge National Laboratory in Oak Ridge, Tenn .
Written in English

    Subjects:
  • Chemical mutagenesis -- Bibliography.

  • Edition Notes

    Statementcompiled by E.S. von Halle ... [et al.]
    GenreBibliography.
    The Physical Object
    Paginationv, 80 p.
    Number of Pages80
    ID Numbers
    Open LibraryOL16617490M

      Inspired by these advances, a pair of large-scale chemical mutagenesis screens were performed by the Driever and Fishman laboratories and Nusslein-Volhard laboratory (12,13).Cited by: The Online Books Page. Online Books by. Oak Ridge National Laboratory. Books from the extended shelves: Oak Ridge National Laboratory: [gamma] correlation with mixtures and polarization./ (Oak Ridge: Oak Ridge National Laboratory, ), also by R. K. Osborn, M. E. Rose, and U.S. Atomic Energy Comnmission (page images at HathiTrust) Oak Ridge National .

    This unique book integrates knowledge from a wide range of expertise, specifically applied to the mouse and addressed at a wide audience from those new to the field to experts who want an update on the state of the art. Mouse Genetics and Transgenics: A Practical Approach covers all aspects of using the mouse as a genetic model organism: care and husbandry; archiving . Chemical mutagenesis in its purest form constitutes the conversion of some precursor side chain to a natural Chemical mutagenesis Chalker and Davis Figure 2 Clark and Lowe’s ‘Chemical Mutations of Papain.’ Cysteine was used as a common precursor to multiple amino acids: formylglycine, glycine, and serine [24,25 ]. edirect.

    Mutation Research - Genetic Toxicology and Environmental Mutagenesis (MRGTEM) publishes papers advancing knowledge in the field of genetic toxicology. Papers are welcomed in the following areas: New developments in genotoxicity testing of chemical agents (e.g. improvements in methodology of assay systems and interpretation of results).   The site of hematopoiesis in vertebrates changes during embryogenesis In mammals, primitive hematopoiesis is largely erythropoietic and occurs outside the embryo in the blood islands of the yolk sac. In later stages of development, hematopoiesis moves to the aorta-gonad-mesonephros region and the fetal liver,15 whereas in adults definitive hematopoiesis Cited by:


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Chemical mutagenesis in laboratory mammals by Edward von Halle Download PDF EPUB FB2

@article{osti_, title = {Chemical mutagenesis in laboratory mammals. A bibliography on the effects of chemicals on germ cells}, author = {Von Halle, E.

S.}, abstractNote = {A list of references is presented on chemical mutagenesis in laboratory mammals. The references relate primarily to chemical effects on germ cells. Mutagenesis starts with introducing double-stranded breaks (DSBs) on chromosomal DNA by ionic irradiation, chemical agents, or nucleases, and then leaving DSBs unrepaired or repaired inaccurately without a homologous donor, resulting in chromosomal rearrangements and mutations (reviewed by Iliakis et al., ).

44 CHEMICAL MUTAGENESIS III. CHROMOSOME BREAKAGE AND MUTATION Because of the relative ease with which cytological observations can be made on cells of actively grow­ ing plant root-tips after they have been exposed to solutions of chemicals, much of the screening of chemical mutagens has been based on the ability to produce chromosome Size: KB.

Chemical mutagenesis The interaction of certain environmental chemical compounds and cell metabolism may result in genetic changes in DNA structure, affecting one or more genes. These chemicalinduced mutations are known as chemical mutagenesis. Many cancers and other degenerative diseases result from acquired genetic mutations due to environmental exposure.

In molecular biology, mutagenesis is an important laboratory technique whereby DNA mutations are deliberately engineered to produce libraries of mutant genes, proteins, strains of bacteria, or other genetically modified various constituents of a gene, as well as its regulatory elements and its gene products, may be mutated so that the functioning of a genetic locus.

Mutagenesis / m juː t ə ˈ dʒ ɛ n ɪ s ɪ s / is a process by which the genetic information of an organism is changed, resulting in a may occur spontaneously in nature, or as a result of exposure to can also be achieved experimentally using laboratory procedures.

Mutagenesis screens using chemical agents such as ethylmethanesulphonate (EMS) or N-ethyl-N-nitrosourea (ENU) are an efficient approach for generating such a resource.

Chemical mutagenesis accelerates forward genetics, i.e. moving from trait to identified gene, and generates valuable alleles for uncovering the diversity of gene by: Site-specific mutagenesis techniques, also known as site-directed mutagenesis (SDM), aim to introduce precise alterations in any coding or noncoding deoxyribonucleic acid.

Thus, many different artificial mutagenesis methods to improve the mutation efficiency have been applied, so far by chemical or physical mutagens in industrial and research settings Recently.

United States. Energy Research and Development Administration. Title(s): Chemical mutagenesis in laboratory mammals: a bibliography on the effects of chemicals on germ cells/ compiled by the Environmental Mutagen Information Center, Information Center Complex, Information Division.

Mutagenesis is defined as the change in the genetic information of an organism in a stable manner by the use of physical and chemical mutagens. It was developed by Charlotte Auerbach. She was the first women scientist to study on the effect of chemical mutagens. Mutagenesis, the act of inducing mutations within an organism’s genome, has been used in plant breeding since Muller’s discovery of the mutagenic effects of X-rays on Drosophila flies (Muller, ).

Table 1 shows a representative sample of the varieties that have been improved using mutagenesis (JointFAO/IAEA, ). The first crop. Chemical mutagenesis.

This chapter discusses the mutagenic effects of alkylating agents and other chemical mutagens (nitrous acid, nitric oxide, base analogues and related compounds, antibiotics, and intercalating agents and topoisomerase poisons) in plants.

Book: Chemical mutagenesis in mammals and man. + pp. Abstract: Although the title does not specifically state the fact, this book is principally concerned with some of the problems of environmental mutagenesis mutagenesis Subject Category: MiscellaneousCited by: The unique experimental system that allows measuring of the level of mutagenesis occurring on leading and lagging DNA strands was developed in our laboratory.

It was used to study the involvement of particular DNA polymerase in replication of leading and/or lagging DNA strand and mechanism of DNA polymerases switching during DNA replication. About this book. Introduction.

The Workshop on Comparative Chemical Mutagenesis was orga­ nized to begin the process of problem identification and resolution concerning our needs to evaluate the data on test chemicals arising from assays for mutagenic activity on laboratory organisms.

In the past, data on chemical mutagens has been. CLASSICAL MUTAGENESIS The specific locus test. Genetic variation — the existence of at least two forms — is the essential ingredient present in all genetic experiments.

Phenotypic variation, in particular, is used as a means for uncovering the normal function of a wild-type allele. We use several strategies to ensure safe use of chemical mutagens: (1) containment of the mutagen in a fume hood during the experiment, (2) inactivation of the mutagen after it is used and (3) isolation of treated fish after mutagenesis to limit the number of workers potentially exposed to the mutagen.

ISBN: OCLC Number: Notes: "Proceedings of the Workshop on Comparative Chemical Mutagenesis, sponsored by NIEHS and held October November 4,at the Crabtree Valley Mall, Raleigh, North Carolina"--Title page verso.

Frederick J. de Serres, Ph. Office of the Associate Director for Genetics National Institute of Environmental Health Sciences Research Triangle Park, North Carolina (U. A.) The Workshop on Comparative Chemical Mutagenesis was orga­ nized to begin the process of problem identification and resolution concerning our needs to evaluate the data on test.

Plant mutagenesis is rapidly coming of age in the aftermath of recent developments in high-resolution molecular and biochemical techniques. By combining the high variation of mutagenised populations with novel screening methods, traits that are almost impossible to identify by conventional breeding are now being developed and characterised at the molecular by: Topics in Chemical Mutagenesis Discontinued Series Although this series no longer publishes new content, the published titles listed below may be still available on-line (e.

g. via the Springer Book Archives) and in print.Important methods to artificially induce mutations are the use of chemical and physical agents. Most chemical mutagens are alkylating agents and azides.

Physical mutagens include electromagnetic radiation, such as γ rays, X rays, and UV light, and particle radiation, such as fast and thermal neutrons, β and α by: